A safe (also called strongbox or coffer) is a secure lockable box used for securing valuable objects against theft or damage. A safe is usually a hollow cuboid or cylinder, with ...
http://en.wikipedia.org/wiki/Safe

Safe Software develops spatial data conversion and distribution software. Our FME solutions enable people to use their spatial data where, when and how they want.
http://www.safe.com/

Located in Tucson, AZ, SAFE is a non-profit 501(c)(3) organization committed to developing a comprehensive, community-based resolution to the euthanasia of adoptable companion ...
http://www.safeanimals.com/

adjective . 1. secure from liability to harm, injury, danger, or risk: a safe place.
http://dictionary.reference.com/search?q=SAFE&r=66

SAFE is a national animal rights organisation that is actively involved in campaigns to protect the welfare of all animals.
http://www.safe.org.nz/